Transporter mediated drug-drug interactions : translation into the clinics
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Chair(s):
Caroline Samer,
Head of Unit / Chair, HUG / IUPHAR Clinical Division, Geneva , Switzerland -
Session description:
Recommendations of the International Transporter Consortium on membrane transporters in drug development
Professor Kathy Giacomini
Professor, UCSF, San Francisco, The United States of AmericaBiomarkers for in vivo assessment of drug transporters
Professor Martin Fromm
Professor, Friedrich-Alexander University, Erlangen, GermanyOral communication speaker - to be confirmed in 2023.
Clinical view and investigations on transporters DDI
Dr Aleksi Tornio
University of Turku, Turku, FinlandUse of PBPK Modeling and Probe Drug Cocktail to assess Transporter-Mediated Drug–Drug Interactions
TBCSponsored by:
Speakers
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Dr Aleksi TornioUniversity of Turku, Turku, Finland
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Dr Manthena VarmaPfizer, Groton, The United States of America
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Professor Kathy GiacominiProfessor in the School of Pharmacy at the University of California; Professor, UCSF, San Francisco, The United States of America
Country: USA
Professor Kathleen (Kathy) Giacomini PhD, a professor in the School of Pharmacy at the University of California, San Francisco, is a leader in the field of membrane transporters with a focus on genetic polymorphisms. She cloned, characterized and discovered endogenous roles of the human xenobiotic transporter, OCT1 (SLC22A1), recently de-orphaned SLC22A24, an anion exchanger that preferentially transports steroid conjugates, and performed genomewide association studies for response to the anti-diabetic drug, metformin and the hypouricemic agent, allopurinol. Together with others, she co-founded the International Transporter Consortium, which has published highly impactful papers informing regulatory policy. She is the Co-Principal Investigator of the UCSF-Stanford Center of Excellence in Regulatory Sciences and Innovation and President of the Pharmacogenomics Research Network. She has received numerous awards and is an elected member of the National Academy of Medicine.
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Professor Martin FrommProfessor, Friedrich-Alexander University, Erlangen, Germany